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Clin Auton Res. 2005 Jun; 3 200-6. ubMed: 5944869Tziomalos K, Krassas GE, Tzotzas T: The use of sibutramine in the management of obesity and related disorders: an update. Hide glossary. Glossary. Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms.

x. In 2002, the EMA asked the manufacturer of Reductil, Abbott Laboratories, to reduce 15mg sibutramine a study into the safety and efficiency of the reduce 15mg sibutramine in a large sample of obese patients. Following the progress of nearly 10, 00 people over six years, and comparing it with a placebo, it was found that the use of Sibutramine only led to modest, short term weight loss, and was more likely to cause heart problems than the placebo.

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Sibutramine (top), ( S )-(−)-sibutramine (bottom)
Clinical data
Trade namesMeridia, others
Pregnancy categoryAU: C US: C (Risk not ruled out) No human data exists; inconclusive evidence of teratogenic potential in animal studies
Routes of administrationOral (capsules)
ATC codeA08AA10 ( WHO )
Legal status
Legal statusUS: Schedule IV
Pharmacokinetic data
BioavailabilityAbsorption 77%, considerable first-pass metabolism
Protein binding97%, (94% for its desmethyl metabolites, M 1 & M 2 )
MetabolismHepatic (CYP3A4-mediated)
Elimination half-life1 hour (sibutramine), 14 hours (M 1 ) & 16 hours (M 2 )
ExcretionUrine (77%), feces (8%)

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