Due to an increased risk of heart attack and stroke in patients with cardiovascular disease, MERIDIA (sibutramine hydrochloride monohydrate) hould not be used in patients with a history of coronary artery MERIDIA (sibutramine hydrochloride monohydrate) UBSTANTIALLY INCREASES BLOOD PRESSURE AND/OR PULSE RATE IN SOME PATIENTS. Sibutramine (slimex) pkg. 10 mg 10 amount of packaging.
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|Sibutramine (top), ( S )-(−)-sibutramine (bottom)|
|Trade names||Meridia, others|
|Pregnancy category||AU: C US: C (Risk not ruled out) No human data exists; inconclusive evidence of teratogenic potential in animal studies|
|Routes of administration||Oral (capsules)|
|ATC code||A08AA10 ( WHO )|
|Legal status||US: Schedule IV|
|Bioavailability||Absorption 77%, considerable first-pass metabolism|
|Protein binding||97%, (94% for its desmethyl metabolites, M 1 & M 2 )|
|Elimination half-life||1 hour (sibutramine), 14 hours (M 1 ) & 16 hours (M 2 )|
|Excretion||Urine (77%), feces (8%)|
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