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In rats, oral doses of either 533 mg/kg sulfamethoxazole or 200 mg/kg trimethoprim produced teratologic effects manifested mainly as cleft palates.
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Pract.Data are limited to date regarding safety of repeated use of co-trimoxazole in pediatric patients younger than 2 years of age; the drug should not be administered prophylactically or for prolonged periods for the treatment of otitis media in any age group.
Various anti-infectives, including oral amoxicillin, oral amoxicillin and clavulanate potassium, various oral cephalosporins cefaclor, cefdinir, cefixime, cefpodoxime proxetil, cefprozil, ceftibuten, cefuroxime axetil, cephalexin IM ceftriaxone, trimethoprim 300mg co-trimoxazole, oral erythromycin-sulfisoxazole, oral azithromycin, oral clarithromycin, and oral loracarbef, have been used in the treatment of AOM. The AAP, CDC, and other clinicians state that, despite the increasing trimethoprim 300mg of trimethoprim 300mg S.
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