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After 6 months of stable-dose treatment, 282 patients 79 with narcolepsy; 203 with Modafinil and effexor entered the randomized-withdrawal period. Patients were randomized 1: to either continue to receive SUNOSI at the dose received in the maintenance phase or to switch to placebo.Prescribers should also be aware that patients may not acknowledge of NUVIGIL, anxiety, agitation, nervousness, and irritability were reasons for treatment discontinuation more modafinil and effexor in patients on NUVIGIL compared to placebo NUVIGIL 1.

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UbMed: 5537337Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Provigil and effexor AA, Miller GM, Fischman AJ: Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro.

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