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Promethazine
Clinical data
Trade namesPhenergan, many others [1]
AHFS/Drugs.comMonograph
MedlinePlusa682284
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, rectal, IV, IM, topical
ATC codeD04AA10 ( WHO ) R06AD02 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral
Pharmacokinetic data
Bioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2]
Protein binding93%
MetabolismLiver glucuronidation and sulfoxidation
Elimination half-life16–19 hours [2] [3]
ExcretionKidney and biliary

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