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Immediate-release formulations do not seem to work. Insomnia.hysiol Behav. 5-802.

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Endogenous Melatonin is Not Obligatory for the Regulation of the Rat Sleep-Wake CycleNuestros datos no proporcionan evidencia de que la melatonina circulante end gena desempe e un papel en la regulaci n del ciclo de sue o-vigilia en ratas.

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37 Polysomnographic recording PSG Actigraph*; Saliva samples**; Blood samples**; Electroencephalogram EEG Accelerometers*; Hours of sleep*; Heart rate/Heart rate variability HR/HRV Melatonin assays*; Multiple sleep latency tes MSLT Urine samples**; 5- min reaction test*762919 reativecommons.

rg/licenses/by/2.Administration of melatonin as melatonin testing treatment to any AE s compared to melatonin testing placebo or no add-on treatment. Review authors independently selected trials for inclusion according to pre-defined criteria, extracted relevant data, and evaluated the methodological quality of trials.

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