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Melatonin
Clinical data
Pronunciation/ ˌ m ɛ l ə ˈ t oʊ n ɪ n / ( listen )
Trade namesMany [1]
AHFS/Drugs.comConsumer Drug Information
License dataEU  EMA:  by INN
Routes of administrationBy mouth, sublingual, transdermal
ATC codeN05CH01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : OTC UK: POM (Prescription only) US: OTC
Pharmacokinetic data
Bioavailability30–50%
MetabolismLiver via CYP1A2 mediated 6-hydroxylation
Metabolites6-hydroxymelatonin, N-acetyl-5lhydroxytryptamine, 5-methoxytryptamine
Elimination half-life30–50 minutes [3]
ExcretionKidney
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OvHealth_InformationODS_Frequently_Asked_Questions. spx 18. Sletten, T. Magee, M. Geoffrey, J. Andy, C. Lovato, N. Kennaway, D. Gwini, S. Bartlett, D. Lockley, S. Lineage, L. Grunstein, R. Rajaratnam, S. Sugary Emetic on Melatonin DelSoM Col Group 2018 Efficacy of melatonin doe melatonin cause gas developmental sleep-wake doe melatonin cause gas for life sleep-wake phase story: A item-blind, randomised controlled trial.

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Melatonin . Melatonin is a hormone made by the pineal gland (tiny organ near the center of the brain). Melatonin helps control the body's sleep ...

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