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Buspirone is a serotonin modulating medication and has been shown to augment esophageal peristaltic amplitude in healthy volunteers. We aimed to determine ...

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Buspirone
Clinical data
Pronunciation/ ˈ b juː s p ɪ r oʊ n / ( BEW -spi-rohn )
Trade namesBuspar
AHFS/Drugs.comMonograph
MedlinePlusa688005
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth
ATC codeN05BE01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability3.9% [4]
Protein binding86–95% [5]
MetabolismLiver (via CYP3A4) [2] [3]
Metabolites5-OH-Buspirone; 6-OH-Buspirone; 8-OH-Buspirone; 1-PP [6] [7] [8]
Elimination half-life2.5 hours [2]
ExcretionUrine: 29–63% [5] Feces: 18–38% [5]

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