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Ann Emerg Med. 2015 Aug. 5-81. Medline.Salicylate poisoning is manifested clinically by disturbances of several organ systems, including the central nervous system CNS and the cardiovascular, pulmonary, hepatic, renal, and metabolic systems. Salicylates directly or indirectly affect most organ systems in the body by uncoupling oxidative phosphorylation, inhibiting Krebs cycle enzymes, and inhibiting amino acid synthesis.
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Consult psychiatric service personnel for patients with intentional overdose. A patient may be discharged following adequate GI tract decontamination with activated charcoal if toxicity is mild, clinical improvement is progressive, acid-base disturbance is not significant, and serial decrease in serum salicylate levels towards the therapeutic range is documented.mile of runway and a speed of 160 miles per hour in order to lift off.
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