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Of these, 14 patients had no prior history of status epilepticus either before treatment or while on other medications.In the U. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20% respectively.

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There are no systematic studies that establish the safety or efficacy of gabapentin as a treatment for people with mood disorders. While such studies are in the planning stages, what is currently known about the use of gabapentin mixed bipolar states in people who have not received adequate relief from carbamazepine and/or valproate.Among patients receiving the gastroretentive formulation of gabapentin in clinical studies, 63% were 65 years of age or older.

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To 1.Pregabalin and gabapentin are considered first-line treatment in the majority of international clinical guidelines for pDPN and form a key part of its management. Five professional bodies have produced expert guidance on the management of pDPN7 11and pregabalin is recommended as first-line therapy in all five guidelines, whilst duloxetine is recommended as first line in four of the guidelines except the American Academy of Neurology 11.

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