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To 25 mg/kg/day (about 10 to 243 times the daily maximum recommended human dose on a mg/m 2 basis) administered by oral gavage for up to 2 years revealed an increase in the incidence of hepatocellular adenoma and carcinoma and uterine stromal polyps in females and thyroid adenoma in males at the high dose. Anastrozole (arimidex) pkg. 1 mg 14 tablets in a package.

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Clinical data
Trade namesArimidex, others
License dataUS   FDA: Anastrozole
Pregnancy categoryUS: D (Evidence of risk) [1]
Routes of administrationBy mouth (tablets)
Drug classAromatase inhibitor; Antiestrogen
ATC codeL02BG03 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding40%
MetabolismLiver (85%)
Elimination half-life46.8 hours [2]
ExcretionUrine (11%)

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